2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Related Products

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Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.

Cannabinoid Receptor Isoform Specific Products:

Cannabinoid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-157833
    Heptadecanoyl ethanolamide
    		Inhibitor
    Heptadecanoyl ethanolamide is an endogenous cannabinoid. Heptadecanoyl ethanolamide is a synthetic analog of PEA which incorporates an odd-numbered (17-carbon) fatty acid chain.
    Heptadecanoyl ethanolamide
  • HY-144827
    AM8936
    		Agonist
    AM8936 acts as a balanced and potent cannabinoid receptor type-1 (CB1) agonist in functional assays (EC50s of 8.6 and 1.4 nM for rCB1 and hCB1, respectively). AM8936 exhibits high affinity for rat CB1 (rCB1) with Ki of 0.55 nM. AM8936 is a potent and efficacious CB1 agonist in vivo. AM8936 can be used for the research of CNS and metabolic disorders, pain, glaucoma, etc.
    AM8936
  • HY-110018S
    N-Arachidonyldopamine-d8
    N-Arachidonyldopamine-d8 is the deuterium labeled N-Arachidonyldopamine[1].
    N-Arachidonyldopamine-d<sub>8</sub>
  • HY-P1090A
    Hemopressin(rat) TFA
    		Antagonist
    Hemopressin(rat) TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) TFA exerts antinociceptive action in inflammatory pain models.
    Hemopressin(rat) TFA
  • HY-118056
    ABD459
    		Antagonist
    ABD459 is a CB1 receptor antagonist with significant effects on regulating food intake and sleep-wake cycles. ABD459 completely displaces CB1 agonist CP99540 (Ki = 8.6 nM) and antagonizes CP55940-induced GTPγS binding (KB = 7.7 nM). ABD459 may specifically modulate endogenous cannabinoid release through cholinergic activity and plays a role in attention and arousal regulation. ABD459 is suitable for research in neurological disorders.
    ABD459
  • HY-120653
    CB1 antagonist 5
    		Antagonist
    CB1 antagonist 5 (Compound 25) is an antagonist for CB1 cannabinoid receptor, with a Ki of 243 nM and an EC50 of 195 nM.
    CB1 antagonist 5
  • HY-110194
    Virodhamine TFA
    		Modulator
    Virodhamine TFA is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine TFA induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine TFA can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases.
    Virodhamine TFA
  • HY-170725
    (-)-11-Hydroxy-Δ8-tetrahydrocannabivarin
    (-)-11-Hydroxy-Δ8-tetrahydrocannabivarin ((-)-11-Hydroxy-Δ8-THCV) is a synthetic cannabinoid.
    (-)-11-Hydroxy-Δ8-tetrahydrocannabivarin
  • HY-170693
    exo-Tetrahydrocannabivarin methyl ether
    exo-Tetrahydrocannabivarin methyl ether (Δ9,11-Tetrahydrocannabivarin methyl ether) is structurally similar to known phytocannabinoids.
    exo-Tetrahydrocannabivarin methyl ether
  • HY-170043
    10(S)-Hydroxy-9(R)-hexahydrocannabinol
    10(S)-Hydroxy-9(R)-hexahydrocannabinol is structurally similar to known phytocannabinoids.
    10(S)-Hydroxy-9(R)-hexahydrocannabinol
  • HY-N0919R
    Yangonin (Standard)
    		Inhibitor
    Yangonin (Standard) is the analytical standard of Yangonin. This product is intended for research and analytical applications. Yangonin exhibits affinity for the human recombinant cannabinoid CB1 receptor with an IC50 and a Ki of 1.79 μM and 0.72 μM, respectively.
    Yangonin (Standard)
  • HY-170710
    Δ8-THC-ethyl
    Δ8-THC-ethyl (Ethyl-Δ8-Tetrahydrocannabinol) is structurally similar to known phytocannabinoids.
    Δ8-THC-ethyl
  • HY-170740
    Cannabigerophorol
    Cannabigerophorol (CBGP) is structurally similar to known synthetic cannabinoids.
    Cannabigerophorol
  • HY-103324
    Palmitoylisopropylamide
    		Inhibitor
    Palmitoylisopropylamide is a Palmitoylethanolamide analogue inhibits [3H]-Anandamide metabolism with a pI50 of 4.89.
    Palmitoylisopropylamide
  • HY-168361
    8β-Hydroxy-exo-THC
    8β-Hydroxy-exo-THC is a cannabinoid ether analogue with a weaker affinity for receptor sites, with an IC50 of 1.2 μM.
    8β-Hydroxy-exo-THC
  • HY-121011
    Cannabigerorcin
    Cannabigerorcin is a phenolic compound found in cannabis plants, featuring a diphenol backbone and a terpene side chain. By reacting with radiolabeled methylmagnesium carbonate (MMC), its carboxyl group can be 14C-labeled. Radiolabeled Cannabigerorcin is widely used in research on cannabinoid biosynthesis pathways and metabolic processes.
    Cannabigerorcin
  • HY-168418
    ADB-BINACA
    ADB-BINACA is categorized as a synthetic cannabinoid.
    ADB-BINACA
  • HY-170699
    Δ8-THCBA-A
    Δ8-THCBA-A (Δ8-Tetrahydrocannabibutolic acid A) is structurally similar to known phytocannabinoids.
    Δ8-THCBA-A
  • HY-134055
    Arachidonoyl-N,N-dimethyl amide
    Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N,N-dimethyl amide is an analog of anandamide that exhibits weak or no binding to the human central cannabinoid (CB1) receptor (Ki >1 μM). It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.
    Arachidonoyl-N,N-dimethyl amide
  • HY-W715183
    6α-Oxycodol N-oxide
    6α-Oxycodol N-oxide is structurally categorized as an opioid. 6α-Oxycodol N-oxide is a metabolite of Oxycodone.
    6α-Oxycodol N-oxide
Cat. No. Product Name / Synonyms Application Reactivity
Cannabinoid Receptor Isoform Comparison

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